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AI-Enabled Anti-Aging Molecule Discovery: AgeXtend

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Credit: The Hindu

Context:

AgeXtend is an AI platform developed by the Indraprastha Institute of Information Technology, Delhi for identifying the anti-aging molecules.

Highlights:

  • It acts as a GPS in the chemical space, guiding researchers to the leads of possible anti-aging molecules.
  • It’s the largest research study done on the subject, scanning more than 1.2 billion molecules.

How it Works?

  • Prediction of Gero Protective properties
    • Geroprotectors are therapeutic interventions that target the root causes of aging to prevent age-related diseases and decline
  • Toxicity evaluation
    • Identification of target proteins and mechanisms of action.
    • Successful identification of compounds such as metformin and taurine as longevity enhancers.
    • Screening of about 1 billion compounds.
  • Application
    • Treatment of senescent diseases and in extending health span.

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