The ribotoxic stress response pathway is a mechanism that senses for stress in cells and initiates stress response programmes. RSR is involved with cell death and inflammation, though it also plays some role in regulation of metabolism.
- How it work?
- The pathway is activated following ribosomal stalling or collision, and the protein MAP3K ZAKα senses the stressed state and can activate the stress-associated mitogen-activated protein (MAP)-kinases p38 and JNK.
- The activated p38 and JNK kinases mediate cell death through pyroptosis and apoptosis, respectively.
- What it Does?
- The RSR is involved in the acute effects of sunburn responses.
- The RSR modulates metabolic responses in cells, nematodes, and mice.
- The RSR modulates blood sugar control, stress hormone production, and survival under starvation conditions.
- What causes it?
- The RSR can be induced by exogenous or endogenous stress signals, plant and microbial toxins, or cell-intrinsic factors.
