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IISc Launches BHARAT Study to Build India-Specific Biomarkers for Healthy Ageing

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Context:

The Indian Institute of Science (IISc) Bengaluru has launched the BHARAT Study to create India-specific reference values for healthy ageing biomarkers. This effort aims to reduce misdiagnosis and improve geriatric care by addressing the limitations of Western-centric medical benchmarks.

What is Healthy Ageing?

Healthy ageing is the process of maintaining physical, mental, and functional well-being in later life. It prioritizes quality of life over mere longevity. Biological age—reflected in organ function or cellular markers—often differs from chronological age.

Key Data & Trends on Ageing in India

  • By 2050, 20% of India’s population (approx. 319 million) will be 60+ (UNFPA India).
  • Disease burden: Parkinson’s cases may rise 168%, and dementia by 200% (Lancet, 2024).
  • Only 28% of the elderly receive formal pension support (NSSO 75th round).
  • Less than 5% of Primary Health Centres have geriatric outpatient services (MoHFW).
  • Gender disparity: Women outlive men but suffer more disability-adjusted life years (DALYs).

Features of Healthy Ageing

  • Functional independence in daily tasks (e.g., cooking, walking).
  • Resilience to stress, such as surgery or infections.
  • Good mental health with low social isolation and depression.
  • Use of preventive biomarkers like CRP, HDL, and metabolite levels.
  • Culturally adapted health standards rather than universal Western benchmarks.

Why India Needs a Contextual Approach

  • Faster ageing transition than OECD peers (e.g., Kerala’s elderly dependency rate to hit 35%).
  • Western lab norms often misinterpret Indian metabolic profiles (e.g., B12 deficiency).
  • Social security void: <20% elderly covered under old age pension schemes.
  • Rural-urban divide in access to geriatric wards and transport.
  • Weakened family care due to nuclearisation of households.

Challenges to Healthy Ageing

  • Data scarcity: Most available biomarkers are based on Western studies like NHANES.
  • Cultural reluctance to medical screening among tribal and rural elders.
  • Low budget priority: NPHCE underfunded within NHM.
  • Sampling bias: Difficulty in finding healthy elderly for baseline samples.
  • Early-life disease burden skews adult ageing trajectories.

Key Initiatives

  • BHARAT Study (IISc): India’s first bio-bank on ageing biomarkers, focusing on local genetic, nutritional, and environmental factors.
  • NPHCE: Offers geriatric clinics and home-based care.
  • LASI (Longitudinal Ageing Study in India): Tracks elder health and functional decline.
  • RSBY / AB PM-JAY: Health insurance for age-related diseases.
  • Medical education: Geriatrics included in MBBS and AYUSH specialisations.

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